Nitration of chemokine cxcl8 acts as a natural mechanism to limit acute inflammation

HIGHLIGHTS

  • who: Sarah Thompson from the Immunity and Inflammation Theme, Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne , HH, UK have published the article: Nitration of chemokine CXCL8 acts as a natural mechanism to limit acute inflammation, in the Journal: (JOURNAL)
  • what: The authors show peroxynitrite nitrates and thereby regulates neutrophil migration and activation. Using cellular assays, animal models, biophysical and structural studies, the authors show that nitration of CXCL8 impairs neutrophil chemotaxis, receptor signaling and GAG binding. The authors show that is the case by measuring binding of wild_type . . .

     

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