Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle — implications for hypoxic pulmonary hypertension

HIGHLIGHTS

• who: March and colleagues from the University of Western Australia, Australia have published the Article: Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle u2014 Implications for hypoxic pulmonary hypertension, in the Journal: (JOURNAL)
• what: The authors examined the effects of sodium nitroprusside (SNP), as NO donor, on the thromboxane-mediated contraction and NO-independent relaxation pathways and on reactive oxygen species (ROS) accumulation in PASMC. The authors focused next on the pathways downstream of prostanoid receptors, as hypoxia increases Gu03b1q coupling of the thromboxane receptor (Fediuk et_al, 2012), and may desensitize . . .
  

   

  

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