Nitric oxide, noc-12, and s-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms

HIGHLIGHTS

  • who: Junhui Sun from the (UNIVERSITY) have published the paper: Nitric Oxide, NOC-12, and S-Nitrosoglutathione Modulate the Skeletal Muscle Calcium Release Channel/Ryanodine Receptor by Different Mechanisms, in the Journal: (JOURNAL) of November/22,/2002
  • what: The authors report that the NO donors NOC-12 and S-nitrosoglutathione both activate RyR1 by release of NO but do so independently of pO2. The authors examined the activation of the skeletal muscle Ca2⫹ release channel by NOC-12 and GSNO, an endogenous S-nitrosothiol, and compared their effects to solutions of NO.

SUMMARY . . .

 

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