Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes inos and mpges-1*

HIGHLIGHTS

• who: Gobeil Fernand Jr. from the (UNIVERSITY) have published the paper: Nitric Oxide Signaling via Nuclearized Endothelial Nitric-oxide Synthase Modulates Expression of the Immediate Early Genes iNOS and mPGES-1*, in the Journal: (JOURNAL) of March/30,/2006
• what: This study has uncovered an alternative noncanonical pathway for intracrine NO signaling associated with immediate early gene_expression, specifically iNOS and mPGES-1, which depends upon a nuclearized eNOS/sGC network.
• how: The authors used the nonpermeable cross-linker reagent BS3 to block cell surface signaling events including those evoked by sLPA in intact . . .
  

   

  

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