Nkg7 enhances cd8+ t cell synapse efficiency to limit inflammation

HIGHLIGHTS

• who: Emily J. Lelliott from the University of Siena, Italy have published the article: NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation, in the Journal: (JOURNAL)
• what: The authors show that NKG7 deficient CD8+ T_cells (from NKG7 deficient mice or following CRISPR/Cas9 editing) fail to effectively kill target cells in_vitro, resulting in prolonged immune synapse formation and hypersecretion of cytokines, including TNF.
• how: Given that MC38-OVA tumors are sensitive to TNFmediated cell death the authors hypothesized that hypersecretion of TNF may overcome the reduced immune synapse-dependent cytotoxic activity . . .
  

   

  

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