Nlrp3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndrome

HIGHLIGHTS

• who: Katerina Theodoropoulou MD PhD from the Lausanne, Switzerland From athe Department of Immunobiology, University of Lausanne, and bthe Pediatric have published the article: NLRP3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndrome, in the Journal: (JOURNAL) of March/15,/2022
• what: The authors investigate the functional role of each LRR-coding exon in natural versus CAPS-induced inflammatory conditions in_vitro. The analysis demonstrates a decrease in exon 4 exclusion in PBMCs treated with IFN-a (Fig 6, A). The authors show that excluding exon 6 and exon 8 . . .
  

   

  

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