Nmda receptor antagonists degrade lipofuscin via autophagy in human retinal pigment epithelial cells

HIGHLIGHTS

  • who: Jae Rim Lee and Kwang Won Jeong from the College of Pharmacy, Gachon Research Institute of Pharmaceutical Sciences, Gachon University have published the research work: NMDA Receptor Antagonists Degrade Lipofuscin via Autophagy in Human Retinal Pigment Epithelial Cells, in the Journal: Medicina 2022, 58, 1129. of 28/06/2022
  • what: This study shows that NMDA in human RPE cells and suggests that NMDA could be promising new therapeutics for retinal degenerative diseases. The authors focused on autophagy as a mechanism for eliminating A2E, a major photooxidative component of lipofuscin.
  • how: To investigate . . .

     

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