Nmr, biophysical, and biochemical studies reveal the minimal calmodulin binding domain of the hiv-1 matrix protein

HIGHLIGHTS

• who: Alexandra B. Samal from the Alexandra BSamal, Ruba H. Ghanam, Timothy F. Fernandez, Eric B. Monroe, and Jamil S. Saad, From the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama , Background: Calmodulin interacts with the , Gag protein in infected cells. Results: The minimal calmodulin binding domain of Gag has been identified. Conclusions: Residues , , of MA are important for CaM binding. Significance: Our findings may help in identification of the functional role of CaM-Gag interactions in the HIV replication cycle. Subcellular distribution of Calmodulin (CaM) in human immunodeficiency virus type, (HIV-1)-infected cells . . .
  

   

  

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