No specific subcellular localization of protein kinase c is required for cytotoxic t cell granule exocytosis*

HIGHLIGHTS

• who: Arun T. Pores-Fernando from the Arun TPores-Fernando, Michelle Y. D. Ranaghan, and Adam Zweifach, From the Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, Cytotoxic T cells kill virus-infected cells and tumor cells by releasing lytic granules that contain cell-killing contents. Exocytosis requires calcium influx and protein kinase C (PKC) activation. Here, we extend our previous finding regarding the lack of isoform specificity of PKCs in the granule release step, showing that mutant constitutively active PKC␦ can substitute for phorbol esters and support exocytosis. PKC␦, a novel PKC isoform . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.