HIGHLIGHTS
SUMMARY
Several studies have demonstrated the de novo formation of lymphatic vessels or the reorganization of lymphatic sinus in tumor-draining lymph nodes, partly preceding the detection of lymphatic metastases. This intranodal lymphangiogenesis can be observed before the detection of lymph node metastasis -supposedly facilitating the survival of metastatic tumor cells in this "lymphovascular niche". Only few studies on nodal lymphangiogenesis in human invasive BC have been published, but these did not examine negative, tumor-free sentinel lymph nodes (SLN) and did not specify tumor types. The authors previously characterized the morphology and immunohistochemical profile . . .
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