HIGHLIGHTS
SUMMARY
Biomedicines11020468 Metabolic syndrome (MetS) has greatly increased in prevalence, along with the exponential increase of obesity worldwide. This evidence has been confirmed by several studies, which reported an increased risk of developing HCC in T2DM patients, even in the absence of alcoholism, obesity, and chronic hepatitis. MAFLD patients with advanced fibrosis and cirrhosis have a higher risk of developing HCC, although HCC can occur even in the absence of advanced fibrosis. It has been observed that patients with MAFLD-HCC have less severe liver damage and dysfunction than patients with HCV-related HCC, as . . .
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