Non-canonical dna/rna structures associated with the pathogenesis of fragile x-associated tremor/ataxia syndrome and fragile x syndrome

HIGHLIGHTS

• who: FMR and collaborators from the School of Medicine, Emory University, United States have published the research work: Non-canonical DNA/RNA structures associated with the pathogenesis of Fragile X-associated tremor/ataxia syndrome and Fragile X syndrome, in the Journal: (JOURNAL)

SUMMARY

Abnormal expansion of CGG repeat tracts above a certain threshold Frontiers in Genetics frontiersin.org 10.3389/fgene.2022.866021 Schneider et_al, 2020). In model systems, hyperexpression of riboCGG repeats in the PM range leads to defects in cell development and cell toxicity (Hagerman, 2012; Hagerman et_al, 2018; Bhat et_al . . .

 



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