Non-canonical proteolytic activation of human prothrombin by subtilisin from bacillus subtilis may shift the procoagulant-anticoagulant equilibrium toward thrombosis

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  • who: Giulia Pontarollo from the Giulia Pontarollo1, Laura Acquasaliente1, Daniele Peterle, Roberta Frasson, Ilaria Artusi, and Vincenzo De Filippis, From the Department of Pharmaceutical and Pharmacological Sciences, University of Padua, via Marzolo, Padua, Italy Edited by George NDeMartino have published the research: Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant-anticoagulant equilibrium toward thrombosis, in the Journal: (JOURNAL) of June/28,/2017
  • what: The authors show that addition of subtilisin (50 nM to 2 ␮M), a serine protease secreted by the non-pathogenic bacterium Bacillus subtilis, induces . . .

     

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