Non-classical phenotypes of mismatch repair deficiency and microsatellite instability in primary and metastatic tumors at different sites in lynch syndrome

HIGHLIGHTS

• who: Zhiyu Li and colleagues from the StVincent`s University Hospital, United Kingdom have published the research work: Non-classical phenotypes of mismatch repair deficiency and microsatellite instability in primary and metastatic tumors at different sites in Lynch syndrome, in the Journal: (JOURNAL)
• what: The authors found that the MSI status of LS-associated tumors differed significantly in the same patients with LS with the same MMR germline variation and MMR-protein expression deletion background; colorectal cancers showed more dMMR/ MSI-H and extraintestinal tumors showed more dMMR/MSI-L and dMMR/MSS.
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