Non-idh1-r132h idh1/2 mutations are associated with increased dna methylation and improved survival in astrocytomas, compared to idh1-r132h mutations

HIGHLIGHTS

• who: C. Mircea S. Tesileanu from the (UNIVERSITY) have published the paper: Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations, in the Journal: (JOURNAL) of 27/Dec/2019
• what: Even though these mutations are confined to distinct hotspots the authors show that gliomas are the only tumour type with an exceptionally high percentage of I­ DH1R132H mutations. For 1p/19q non-codeleted glioma (astrocytoma) patients the authors show that this difference is clinically relevant: in samples of the randomised phase III . . .
  

   

  

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