HIGHLIGHTS
- who: Britt Hanson from the University of, South Parks Road, Oxford , QX, UK have published the Article: Non-uniform dystrophin re-expression after CRISPR-mediated exon excision in the dystrophin/utrophin double-knockout mouse model of DMD, in the Journal: (JOURNAL) of 30/Dec/2022
- what: The authors report Dmd gene editing and dystrophin restoration in the severely affected dKO mouse model of DMD using an AAV-delivered (two vector), double-cut CRISPR strategy. The authors propose that inefficient editing using this approach will inevitably lead to the generation of chimeric fibers containing both dystrophinexpressing . . .
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