Non-viral precision t cell receptor replacement for personalized cell therapy

HIGHLIGHTS

• who: Susan P. Foy from the (UNIVERSITY) have published the research work: Non-viral precision Tu2009cell receptor replacement for personalized cell therapy, in the Journal: (JOURNAL) of 16/06/2022
• what: This study shows the feasibility of isolating and cloning multiple TCRs that recognize mutational neoantigens. The authors focused on TCR functionality and TCR binding in CD8 and CD4 T_cells, diversifying among HLAs and the targeted neoantigens and clonality of the targeted neoantigen (Extended Data Table 2).
• how: The authors developed a clinical-grade approach based on CRISPR-Cas9 non-viral precision genome . . .
  

   

  

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