HIGHLIGHTS
- who: Jiqin Zhang from the (UNIVERSITY) have published the article: Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL, in the Journal: (JOURNAL) of 29/03/2021
- how: Altogether these scRNA-seq data showed that PD1-19bbz cells have an increased number of memory T_cells and enhanced anti-tumour immune functions thus giving a mechanistic explanation for their high efficacy. The results are also consistent with two recently reported clinical trials3940 and accordingly further demonstrate the safety of CRISPR-Cas9 application in T_cell therapy.
SUMMARY
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