HIGHLIGHTS
- who: Carla Iacobini and collaborators from the Department of Clinical and Molecular Medicine, "La Sapienza" University, Rome, Italy have published the article: Normalizing HIF-1 Signaling Improves Cellular Glucose Metabolism and Blocks the Pathological Pathways of Hyperglycemic Damage, in the Journal: Biomedicines 2021, 9, 1139. of /2021/
- what: By using human endothelial cells and macrophages the authors demonstrate that high glucose (HG) induces HIF-1α activity and a switch from oxidative metabolism to glycolysis and its principal branches. This study provides a new mechanistic explanation, alternative to mitochondrial superoxide overproduction, for the initial changes in . . .
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