HIGHLIGHTS
- who: TYPE and collaborators from the Leeds Beckett University, United Kingdom have published the research work: Not sorcery after all: Roles of multiple charged residues in membrane insertion of gasdermin-A3, in the Journal: (JOURNAL)
SUMMARY
A couple of mechanisms have been suggested before to aid the insertion of charged amino_acids into hydrophobic membrane cores. The simulations have revealed that the salt-bridge formation between E94 and K100 and the polar protein surroundings of all three charged residues drastically decrease the energy barrier for membrane insertion of GSDMA3`s β-hairpins, in comparison to . . .
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