Notch-signaling deregulation induces myeloid-derived suppressor cells in t-cell acute lymphoblastic leukemia

HIGHLIGHTS

• who: Paola Grazioli from the Department of Experimental Medicine, Sapienza University, Rome, Italy, Department of Molecular Medicine, Sapienza have published the article: Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia, in the Journal: (JOURNAL)
• what: The authors demonstrate that functional CD11b+Gr-1+ MDSCs accumulate in a transgenic murine model of Notch3-dependent TALL (N3-tg mice), bearing an lck-driven constitutive expression of ICN3 in T_cells . Now, the authors report a marked expansion of the CD11b+Gr-1+ myeloid subset in the spleen of N3-tg mice, when . . .
  

   

  

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