Notch signaling mutations increase intra-tumor chemokine expression and predict response to immunotherapy in colorectal cancer

HIGHLIGHTS

  • who: Fei Wang from the Department of Oncology, Guangdong Provincial People's Hospital, China have published the research work: Notch signaling mutations increase intra-tumor chemokine expression and predict response to immunotherapy in colorectal cancer, in the Journal: (JOURNAL)
  • what: The authors aim to investigate the underlying mechanism and the predictive potential of for responding to in CRC. In this study, only the mutations of NOTCH1, NOTCH2, NOTCH3, NOTCH4 and FBXW7 were assessed.
  • how: The datasets included fit the following criteria(1) CRC patients of the dataset underwent immunotherapy gene mutation was detected . . .

     

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