HIGHLIGHTS
- who: Emilie Abby from the Division Stratified epithelium Submucosa have published the research: Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth, in the Journal: (JOURNAL) of 25/03/2021
SUMMARY
Sequencing NOTCH1 mutant clones in aging human esophagus reveals frequent biallelic mutations that block NOTCH1 signaling. The authors conclude that Notch1 mutations in normal epithelium are beneficial as wild-type Notch1 favors tumor expansion. The authors Nature Genetics NOTCH1 mutant clones in human esophagus Deep targeted sequencing studies have revealed numerous NOTCH1 mutants in human esophagus but have . . .
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