HIGHLIGHTS
- who: Qirong Xu and colleagues from the Department of Thoracic Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China have published the article: Notch1 Protects against Ischemic-Reperfusion Injury by Suppressing PTEN-Pink1-Mediated Mitochondrial Dysfunction and Mitophagy, in the Journal: Cells 2023, 12, 137. of 15/Oct/2022
- what: The authors explore the role of the downstream target in regulation. The authors demonstrate that Notch1 impairs the elevated expression of PETN in I/R heart injuries and cardiomyocytes. The authors demonstrate that Notch1 preserves mitochondrial respiration and inhibits mitochondrial fragmentation by suppressing the Pink1 . . .
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