Novel 9-benzylaminoacridine derivatives as dual inhibitors of phosphodiesterase 5 and topoisomerase ii for the treatment of colon cancer

HIGHLIGHTS

  • who: Lina Ammar et al. from the Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt School of Medicine, College of Medicine, University, Kaohsiung, Taiwan have published the article: Novel 9-Benzylaminoacridine Derivatives as Dual Inhibitors of Phosphodiesterase 5 and Topoisomerase II for the Treatment of Colon Cancer, in the Journal: Molecules 2023, 840 of 14/01/2023
  • what: PDE5 inhibitors have been reported in several studies in the context of dually acting compounds [49,51-53].
  • how: All the synthesized acridine derivatives were tested for their . . .

     

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