Novel affibody molecules targeting the axl extracellular structural domain for molecular imaging and targeted therapy of gastric cancer

HIGHLIGHTS

• What: The authors report the novel AXLbinding affibody molecules ­(ZAXL:239) screened by a phage-displayed peptide library. The authors provide strong evidence that the novel ­ZAXL:239 affibody molecules have great potential as a potent tumor-specific molecular imaging and targeted therapeutic agents for GC. The authors showed that AXL is upregulated in GC tissue and that its high expression is associated with a poorer prognosis in patients.
• Who: HuiHui Zhang from the Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang . . .
  

   

  

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