Novel allosteric mechanism of dual p53/mdm2 and p53/mdm4 inhibition by a small molecule

HIGHLIGHTS

• who: Vera V. Grinkevich and collaborators from the Clemson University, United States have published the paper: Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule, in the Journal: (JOURNAL)
• what: Based on the results , the authors propose a model of a novel allosteric mechanism of p53 reactivation which is triggered by binding to the region spanning residues 33-37 of human p53. Next, the authors propose that constraints imposed by RITA prevent solvent exposure of F19, W23 and L26 residues, thus counteracting the p53/ MDM2 interaction . The authors propose . . .
  

   

  

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