Novel broad-spectrum antiviral inhibitors targeting host factors essential for replication of pathogenic rna viruses

HIGHLIGHTS

• who: Marianna Tampere et al. from the Department of Microbiology, Public Health Agency of Sweden, , Stockholm, SwedenDepartment of Molecular Medicine, University of Padova, Padova, Italy have published the research work: Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses, in the Journal: (JOURNAL)
• what: Based on thermal destabilization of cytosolic Hsp70 and stabilization of numerous co-chaperones, the authors propose that TH6744 binds to co-chaperones of Hsp70 multiprotein complexes resulting in Hsp70 thermal destabilization and thereby impairing the function of Hsp70.
• how: The authors identified novel . . .
  

   

  

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