HIGHLIGHTS
- who: Admin from the Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand have published the article: Novel Inhibitor Scaffold for EGFR (L858R/T790M/C797S) Tyrosine Kinase: Molecular Docking Biological Evaluations and Computational Insights, in the Journal: Molecules 2022, 8901. of 14/Dec/2022
- what: The authors found that all screened compounds could interact with M793 at the hinge regions and two mutated residues including M790 and S797; which may be the main reason supporting the inhibitory activity in vitro. Altogether this study proposes a novel EGFR (L858R/T790M/C797S) TK inhibitor scaffold and . . .
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