Novel inhibitors and activity-based probes targeting serine proteases

HIGHLIGHTS

• who: CF and collaborators from the University of Oxford, United Kingdom have published the paper: Novel inhibitors and activity-based probes targeting serine proteases, in the Journal: (JOURNAL) of 31/08/2021
• what: This work has led to the identification of a highly specific, cell-permeable, small_molecule, an inhibitor of furin (BOS-318), which also restores ASL height and mucociliary function (Douglas et_al, 2022). initiate mast cell activation/sensitization and cause disruption of epithelial barriers, in a range of human allergic conditions (Montealegre et_al, 2004; Arizmendi et_al, 2011; Argrawal and Arora, 2018; Li et_al, 2019 . . .
  

   

  

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