Novel n-normetazocine derivatives with opioid agonist/sigma-1 receptor antagonist profile as potential analgesics in inflammatory pain

HIGHLIGHTS

• who: Rita Turnaturi et al. from the Department of Drug and Health Sciences, Medicinal Chemistry Section, University of Catania, Viale ADoria, Catania, Italy have published the research work: Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain, in the Journal: Molecules 2022, 5135 of 12/08/2022
• what: (-)-2R/S-LP2 (1), (-)-2R-LP2 (2), and (-)-2S-LP2 (3) compounds exhibited a multitarget opioid/u03c31R profile.
• how: The same result was before formalin by the i.p.The route not alter the severity of . . .
  

   

  

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