Novel p.g250a mutation associated with chronic pancreatitis highlights misfolding-prone region in carboxypeptidase a1 (cpa1)

HIGHLIGHTS

• who: Mu00e1tu00e9 Su00e1ndor and colleagues from the Department of Surgery, University of California Los Angeles, Los Angeles, CA, USA have published the research work: Novel p.G250A Mutation Associated with Chronic Pancreatitis Highlights Misfolding-Prone Region in Carboxypeptidase A1 (CPA1), in the Journal: (JOURNAL) of 30/Oct/2022
• what: The authors propose that disease-causing mutations exhibit abolished or markedly reduced secretion with pronounced ER stress whereas mutations with milder misfolding phenotypes may be associated with lower disease risk or may not be pathogenic at all. The authors report the functional characterization of a novel . . .
  

   

  

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