Novel plasmodium antigens identified via genome-based antibody screen induce protection associated with polyfunctional t cell responses

HIGHLIGHTS

• who: Sophie Schussek from the (UNIVERSITY) have published the article: Novel Plasmodium antigens identified via genome-based antibody screen induce protection associated with polyfunctional T cell responses, in the Journal: (JOURNAL) of 21/06/2017
• what: The authors show that the Plasmodium yoelii orthologs of four Plasmodium falciparum proteins identified by an antibody-based genome-wide screening strategy induce a high degree of sterile infection-blocking protection against sporozoite challenge in a stringent rodent malaria model. In a first analysis the authors focused on the production of each cytokine individually by CD8+ or CD4+ T_cell . . .
  

   

  

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