Novel sigma-2 receptor ligand a011 overcomes mdr in adriamycin-resistant human breast cancer cells by modulating abcb1 and abcg2 transporter function

HIGHLIGHTS

• who: MCF- and colleagues from the University, Japan have published the Article: Novel Sigma-2 receptor ligand A011 overcomes MDR in adriamycin-resistant human breast cancer cells by modulating ABCB1 and ABCG2 transporter function, in the Journal: (JOURNAL)
• what: The authors found that σ2 ligand A011 showed significant cytotoxic activity in three tumor cell lines MCF-7, A549 and HepG2 cells and generally showed no decrease in cytotoxic activity in drug-resistant cell lines MCF-7/ADR, A549/DDP and HepG2/DDP cells.
• how: The results showed that A011 at 1.25 and . . .
  

   

  

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