Novel small molecule positive allosteric modulator spam1 triggers the nuclear translocation of pac1-r to exert neuroprotective effects through neuron-restrictive silencer factor

HIGHLIGHTS

• who: Guangchun Fan and colleagues from the Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China have published the Article: Novel Small Molecule Positive Allosteric Modulator SPAM1 Triggers the Nuclear Translocation of PAC1-R to Exert Neuroprotective Effects through Neuron-Restrictive Silencer Factor, in the Journal: (JOURNAL) of 28/Nov/2022
• what: In this report, the authors attempt to reveal the details of the mechanism by which PAMs targeting PAC1-R, such as SPAM1, exert neuroprotective activity by regulating the neuron-restrictive silencer factor (NRSF). The authors report that SPAM1 . . .
  

   

  

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