Novel staphylococcal glycosyltransferases sdga and sdgb mediate immunogenicity and protection of virulence-associated cell wall proteins

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  • who: Wouter L. W. Hazenbos and colleagues from the Division of Infectious Diseases, University of California, San Francisco, California, United States of America, Antibody Engineering, Genentech, Inc, San Francisco have published the article: Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins, in the Journal: (JOURNAL) of October/10,/2013
  • what: The authors propose that Sdg-mediated glycosylation of SDR proteins is a bacterial mechanism of protection against host innate immunity, to safeguard efficient host tissue colonization. Based on reactivity of the patient-derived, glycosylationspecific monoclonal antibody rF1 . . .

     

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