HIGHLIGHTS
- who: Wei Wang from the Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China have published the research: NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway, in the Journal: (JOURNAL)
- what: The authors report the function of NOX4 in wear particle-mediated PPO and explored possible mechanisms using RANKL-induced osteoclastogenesis in_vitro and a Ti nanoparticle-induced model of osteolysis in_vivo. The authors further investigated whether NOX4 inhibition could protect against Ti nanoparticle-induced bone loss.
- how: This study was conducted in . . .
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