Noxa and mcl-1 expression influence the sensitivity to bh3-mimetics that target bcl-xl in patient-derived glioma stem cells

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    To evaluate the endogenous expression levels of anti-apoptotic factors, the authors performed RT-qPCR and Western blot analysis of Bcl-2, Bcl-w, Bcl-xL, and Mcl-1 in GSC-ECLs (named G01, G02, G03, G07, G08, and G09) and in untransformed neural progenitors (NP). The authors found that Bcl-2 expression is more abundant in NPs, while Bcl-w showed higher expression levels in GSC-ECLs. Although the abundance of Bcl-xL and Mcl-1 is similar between NP and GSC-ECLs, the G03 cell line exhibited higher expression levels of Bcl . . .

     

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