Nrf2 activation confers resistance to eif4a inhibitors in cancer therapy

HIGHLIGHTS

  • who: Viraj R. Sanghvi and colleagues from the Department of Molecular and Cellular Pharmacology, Sylvester Comprehensive Center, Miller School of Medicine, University of Miami, Miami, FL, USA have published the article: NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy, in the Journal: Cancers 2021, 639. of 29/01/2021
  • what: The authors examine the effect of a synthetic eIF4A inhibitor (CR-1-31 B) against aggressive, MYC and BCL2 positive lymphomas and the authors specifically explore potential mechanisms of resistance to the eIF4A inhibitor treatment.
  • how: For immunoblotting the authors used . . .

     

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