HIGHLIGHTS
SUMMARY
In this regard, this article intends to analyze in depth the mechanism of Nrf2 as the main regulator of oxidative stress, also summarizing the natural compounds based on the regulation of the Nrf2 pathway for the future development of more effective treatments for TBI and SCI. The authors have specifically selected in_vivo and in_vitro studies that describe the progress of the investigations of natural compounds in the activation of3Nrf2 Int. Its properties were tested in an in_vitro model of H2 O2 -induced oxidative stress in primary cortical neurons. In vivo Nrf2/HO-1 pathway . . .
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