Nrf2 and parkin-hsc70 regulate the expression and protein stability of p62/sqstm1 under hypoxia

HIGHLIGHTS

  • who: Ferbian Milas Siswanto from the DepartmentUniversity, Sanda, Japan Program of Biomedical Science have published the paper: Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia, in the Journal: Scientific Reports Scientific Reports
  • how: These results indicated that HIF-1u03b1 bound to the first HRE in hypoxia and enhanced the transcription of Parkin.

SUMMARY

    Hep3B cells were incubated under hypoxia ­(O2=1%) for 2, 4, 6, 8, and 12 h, and the protein level of p62 was evaluated using immunoblotting. To establish whether hypoxia reduced . . .

     

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