HIGHLIGHTS
SUMMARY
Zeocin has been reported to provoke an arrest in G2 during which DNA segregation toward the daughter cell is paused, whereas nuclear envelope expansion continues, leading to the accumulation of overgrown nuclear membranes, a phenotype that is not triggered by HU (Witkin et al, 2012). Although cell arrest in G2 could be a necessary trigger, it is manifestly not sufficient, for cells treated with CPT or 4-NQO also accumulate in G2/M (Fig 1C) without displaying "nuclear holes" (Figs 1B and S1B). Phosphatidic acid supports the formation of zeocin-triggered nuclear holes Given . . .
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