Nuclear localization of mitochondrial tca cycle enzymes modulates pluripotency via histone acetylation

HIGHLIGHTS

• who: Wei Li from the (UNIVERSITY) have published the Article: Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation, in the Journal: (JOURNAL) of 14/01/2022
• what: The authors show that TCA cycle enzymes including Pdha1, Pcb, Aco2, Cs, Idh3a, Ogdh, Sdha and Mdh2 are translocated to the nucleus during somatic cell reprogramming, primed-to-naive transition and totipotency acquisition. The authors focused on Pdha1, an important subunit of the PDH complex which converts pyruvate to acetyl-CoA26. The authors propose another pathway, in which nuclear translocation of Pdha1 fuels the . . .
  

   

  

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