Nuclear p53-mediated repression of autophagy involves pink1 transcriptional down-regulation

HIGHLIGHTS

• who: Thomas Goiran from the Université Côte d'Azur, INSERM, CNRS, IPMC, team labeled "Laboratory of Excellence (LABEX) Distalz", route des Lucioles, Sophia-Antipolis, Valbonne, France have published the research work: Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation, in the Journal: (JOURNAL)
• what: The authors show that transcriptional activity of p53 also contributes to autophagy down-regulation. The authors establish that deletion of an identified p53 responsive element on PINK1 promoter impacts p53-mediated PINK1 transcriptional repression and the authors demonstrate a p53-PINK1 physical interaction by chromatin immunoprecipitation. The . . .
  

   

  

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