Nucleolin rescues tdp-43 toxicity in yeast and human cell models

HIGHLIGHTS

  • who: Caterina Peggion and Raffaele Lopreiato from the Department of Biomedical Sciences, University of Padova, Padova, Italy, CNR, Neuroscience Institute, Padova, Italy have published the paper: Nucleolin Rescues TDP-43 Toxicity in Yeast and Human Cell Models, in the Journal: (JOURNAL)
  • what: The aim of this strategy was the generation of yeast models for TDP-43 proteinopathies expressing the protein at finely tuned levels that may be optimally suited for the functional analysis of potential modulators of the TDP-43 cytotoxicity. The authors focused the attention on NCL as a possible modifier of TDP-43 . . .

     

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