HIGHLIGHTS
- who: Melanie Walter from the (UNIVERSITY) have published the paper: NUDT22 promotes cancer growth through pyrimidine salvage, in the Journal: (JOURNAL) of 23/05/2022
- what: The authors show that cancer tissues have elevated levels of NUDT22 and that NUDT22 expression is directly regulated by p53 following metabolic stress, cMYC overexpression, and DNA damage.
- how: The authors chose p53 wildtype osteosarcoma (U2OS) cancer cells and retina pigment epithelial (hTERT-RPE1) fibroblasts as model systems. The data were analysed with CellProfiler-3.0.0 or Zen blue (Zeiss).
SUMMARY
Genetic . . .
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