Nutrient regulation of the islet epigenome controls adaptive insulin secretion

HIGHLIGHTS

• who: Matthew Wortham and collaborators from the DepartmentsUniversity of Medicine, UCD, Davis, California, USA have published the research: Nutrient regulation of the islet epigenome controls adaptive insulin secretion, in the Journal: (JOURNAL)
• what: The authors show that feeding and fasting remodel the islet epigenome in an Lsd1-dependent manner to adapt the insulin-secretory response. This experiment demonstrates that Lsd1 has a context-specific role in dampening insulin secretion during physiological adaptation to feeding. The authors focused on Nr4a1 . This short-term effect is accompanied by changes to the epigenome and the transcriptome that the . . .
  

   

  

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