O-glcnac transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission

HIGHLIGHTS

• who: Jun Fan from the School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PRChina have published the Article: O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission, in the Journal: (JOURNAL)
• what: The authors show that Ogt mRNA was increased in depression patients and that astroglial OGT expression was specifically upregulated in the medial prefrontal cortex of susceptible mice after chronic social defeat stress. The authors show that a metabolic and stress sensor, OGT, was enriched in astrocytes and neurons. Although the authors show that social stress increases . . .
  

   

  

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