Oasl phase condensation induces amyloid-like fibrillation of ripk3 to promote virus-induced necroptosis

HIGHLIGHTS

• who: Shin-Ae Lee from the (UNIVERSITY) have published the article: OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis, in the Journal: (JOURNAL) of 26/04/2021
• what: The study demonstrates an interferon-induced innate response whereby OASL scaffolds RIPK3-ZBP1 assembly via its phase-separated liquid droplets to facilitate necroptosis-mediated antiviral immunity.
• how: OASL is required for efficient virus-induced necroptosis To delineate the mechanism of RIPK3-OASL interactions the authors used the CRISPR-Cas9 system to generate an OASL1 homozygous null knockout (Oasl1-/-) mouse . . .
  

   

  

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