Obesity by high-fat diet increases pain sensitivity by reprogramming branched-chain amino acid catabolism in dorsal root ganglia

HIGHLIGHTS

• who: Peilin Lu and Tao Li from the The Education University China have published the Article: Obesity by High-Fat Diet Increases Pain Sensitivity by Reprogramming Branched-Chain Amino Acid Catabolism in Dorsal Root Ganglia, in the Journal: (JOURNAL)
• what: The authors report that 8 weeks of HFD feeding impairs BCAA catabolism in mouse DRG, as evidenced by decreased protein expression of PPC2m and increased phosphorylation of BCKDH, and the resulted higher level of BCAAs in DRG is closely correlated with the sensitivity of mice to mechanical and thermal stimuli. The authors demonstrated that HFD . . .
  

   

  

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